Choose the most appropriate answer from the options given below:

Arrange the following physiological responses to stress sequentially:
A. Release of Adrenocorticotropic hormone from pituitary gland
B. Release of CRF from hypothalamus
C. Perception of stress
D. Suppression of immune system functioning
E. Glucocorticoid release from adrenal gland

Correct option is B

The correct sequence of events in the physiological response to stress is:
C. Perception of stress: The stress response begins when the brain perceives a stressor.
B. Release of CRF from hypothalamus: The hypothalamus releases corticotropin-releasing factor (CRF) as a response to the perception of stress.
A. Release of Adrenocorticotropic hormone (ACTH) from pituitary gland: CRF stimulates the pituitary gland to release ACTH.
E. Glucocorticoid release from adrenal gland: ACTH stimulates the adrenal glands to release glucocorticoids (like cortisol) into the bloodstream.
D. Suppression of immune system functioning: The elevated levels of glucocorticoids suppress immune function as part of the body's stress response.

Information Booster:
    -Glucocorticoids are a class of steroid hormones produced by the adrenal cortex that regulate metabolism, immune response, and stress adaptation.
Key Functions:
    -Stress Response: Released during stress (e.g., cortisol) to help the body adapt.
    -Metabolism Regulation: Increases glucose production and influences fat and protein metabolism.
    -Anti-Inflammatory Effects: Suppresses immune responses and reduces inflammation.
    -Blood Pressure Maintenance: Helps regulate cardiovascular function.
    -Cognitive Effects: Affects memory, learning, and emotional regulation.
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    Excess & Deficiency Effects:
        -Excess: Leads to Cushing’s syndrome (weight gain, high blood sugar, hypertension).
        -Deficiency: Causes Addison’s disease (fatigue, weight loss, low blood pressure).