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    A patient with central diabetes insipidus is started on desmopressin. After treatment, urine specific gravity rises from 1.002 to 1.015. What does thi
    Question

    A patient with central diabetes insipidus is started on desmopressin. After treatment, urine specific gravity rises from 1.002 to 1.015. What does this indicate?

    A.

    Treatment is effective, concentrating ability restored

    B.

    Patient has nephrogenic DI, no response to desmopressin

    C.

    Treatment failure, dose must be doubled

    D.

    Patient has developed SIADH

    Correct option is A

    Desmopressin acts as synthetic ADH. A rise in urine specific gravity to 1.015 shows restored renal concentrating ability, confirming effective therapy in central DI.
    Explanation of options: (a) ✔ Correct; increase in urine SG shows response. (b) ✘ Nephrogenic DI = no rise in SG. (c) ✘ Dose adjustment not needed; therapy working. (d) ✘ SIADH would cause excessively high SG, hyponatremia.

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