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A patient with acute severe abdominal pain and vomiting is suspected of acute pancreatitis. Which enzyme level is most specific for diagnosis?
Question

A patient with acute severe abdominal pain and vomiting is suspected of acute pancreatitis. Which enzyme level is most specific for diagnosis?

A.

Serum amylase

B.

Serum lipase

C.

Serum alkaline phosphatase

D.

Serum LDH

Correct option is B

Both amylase and lipase rise in pancreatitis, but lipase is more specific and remains elevated longer. Amylase may also rise in other abdominal conditions.
Explanation of options: (a) ✘ Amylase rises but lacks specificity (also ↑ in perforation, mumps). (b) ✔ Correct; lipase is more specific and sensitive for pancreatitis. (c) ✘ ALP indicates hepatobiliary obstruction, not pancreas. (d) ✘ LDH is nonspecific, not used for pancreatitis.

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