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Which of the following is true about inactivated (killed) vaccines?
Question

Which of the following is true about inactivated (killed) vaccines?

A.

They usually require multiple booster doses for long-term immunity

B.

They revert to virulence in immunocompromised patients

C.

They induce stronger cellular immunity than live vaccines

D.

They are contraindicated in pregnancy

Correct option is A

Killed vaccines are safe but weakly immunogenic, inducing mainly humoral immunity. Hence, multiple booster doses are needed to sustain protection.
Explanation of options: (a) ✔ Correct; killed vaccines (e.g., polio, hepatitis A) require boosters. (b) ✘ Only live vaccines can revert to virulence, not killed ones. (c) ✘ Cellular immunity is weaker compared to live vaccines. (d) ✘ Inactivated vaccines are safe in pregnancy (e.g., influenza).

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