Which of the following is not a product of recombinant DNA technology? Identify those and select the correct answer from the codes given below.
(1) Monoclonal antibody
(2) Humulin
(3) Terramycin
(4) Streptokinase
Codes:

Correct option is A

Correct Answer: (a)
Explanation:
Terramycin (oxytetracycline) is an antibiotic obtained by fermentation of Streptomyces and is not produced by recombinant DNA technology. Humulin (human insulin), recombinant streptokinase, and modern therapeutic monoclonal antibodies are produced using cloned genes in host cells—i.e., rDNA products.
Information Booster:
rDNA products are made by cloning a gene into a vector and expressing it in a host.
Humulin was the first FDA-approved recombinant therapeutic protein.
Streptokinase/tPA used as clot busters have recombinant forms.
Many clinical mAbs today are recombinant (humanized/fully human) produced in CHO cells.
Classical antibiotics like terramycin come from microbial secondary metabolism, not gene cloning.
Additional Information (Incorrect Options):
(a) Monoclonal antibodies: currently produced recombinantly → rDNA.
(b) Humulin: classic rDNA success story.
(d) Streptokinase: widely available as a recombinant protein.
Hence, only (c) fits the “not rDNA” criterion.