Which of the following approaches is not used by doctors in gene therapy?

Correct option is A

Answer: (a) Activate mutated genes
Explanation:
Gene therapy is a medical technique used to treat or prevent diseases by modifying genes within a person's cells. The primary approaches include:
1. Deactivating the mutated gene (b):
· In diseases caused by harmful gene activity, doctors use gene therapy to turn off or silence the defective gene (e.g., using RNA interference or CRISPR).
2. Insertion of a new gene into the body (c):
· Doctors introduce a functional gene into a patient's cells to replace a defective or missing gene (e.g., inserting a healthy gene for cystic fibrosis treatment).
3. Changing the gene that causes a disease (d):
· Using techniques like CRISPR-Cas9 gene editing, doctors can correct mutations directly in a patient’s DNA.
Why Option (a) is Incorrect?
· Activating a mutated gene is not a goal of gene therapy because mutations often cause harmful effects. Instead of activating, gene therapy aims to fix, silence, or replace the defective gene.
Conclusion:
Since activating mutated genes is not a part of gene therapy, the correct answer is: (a) Activate mutated genes.