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Which heavy metal toxicity inhibits the enzymes of heme synthesis causing severe anemia?
Question

Which heavy metal toxicity inhibits the enzymes of heme synthesis causing severe anemia?

A.

Lead

B.

Arsenic

C.

Aluminium

D.

Cadmium

Correct option is A

Lead toxicity inhibits key enzymes like ALA dehydratase and ferrochelatase in the heme biosynthesis pathway, leading to accumulation of precursors and resulting in severe anemia. It also causes basophilic stippling in RBCs.

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