Which disease is caused by the accumulation of lipids in brain cells due to the deficiency or inactivation of lipid digesting enzymes?

Correct option is D

​The correct answer is: (D) Tay-Sachs disease
​Explanation:
● Tay-Sachs disease occurs due to the deficiency of the enzyme Hexosaminidase-A, which leads to the accumulation of lipids (GM2 gangliosides) inside brain nerve cells.
● This buildup causes progressive damage to the nervous system.
● It is a fatal genetic disorder usually seen in infants.
​Information Booster:
● Caused by mutation in the HEXA gene.
● Inherited as an autosomal recessive disorder.
● Symptoms: paralysis, seizures, vision & hearing loss.
● No cure; supportive care only.
● Lipid buildup causes swelling and death of neurons.
​Additional Knowledge:
● Option A – Alzheimer’s disease: Caused by amyloid plaques & tau tangles.
● Option B – Huntington’s disease: Caused by mutation in HTT gene (CAG repeats).
● Option C – Parkinson’s disease: Caused by dopamine deficiency due to degeneration of substantia nigra.​