Correct option is B
Correct Answer:
(b) A > B > C > D
Explanation:
Spontaneous cis–trans isomerization of proline is the slowest process due to a high activation energy barrier and often requires peptidyl-prolyl isomerases.
Co-translational folding occurs on the seconds timescale, limited by ribosomal translation.
α-helix formation is a very fast conformational event occurring within microseconds.
Hydrogen bond formation in free water is the fastest, occurring on femtosecond to picosecond timescales.
Information Booster :
· Proline isomerization is a major rate-limiting step in protein folding.
· Many proteins rely on chaperones and isomerases to speed up folding.
· Secondary structure elements such as α-helices form extremely rapidly.
· Molecular interactions in water occur at ultrafast physical timescales.
Additional Information (Incorrect Options):
Options (a) and (c): Incorrectly place hydrogen bond formation as a slow process.
Option (d): Misorders α-helix formation and hydrogen bond dynamics.
Hydrogen bonding in water is always the fastest among the listed processes.
