Correct option is B
The correct substitution of the highlighted words is (b) must apply yourself to.
Explanation: The correct structure requires a reflexive verb followed by a prepositional phrase. "Apply yourself to something" means to put effort into it.
Grammatical rule used:
When using “apply” in the context of making effort, it is a reflexive verb and must be followed by “to” and the activity.
Example: You must apply yourself to your studies to succeed.
Why other options are incorrect:
· (a) should applied in: Wrong tense and incorrect preposition ("should apply" is correct, and "in" is wrong usage)
· (c) No improvement: Incorrect as “apply in” is not idiomatically or grammatically correct in this context
· (d) ought to apply yourselves in: Incorrect pronoun "yourselves" (subject is singular) and incorrect preposition "in"