Correct option is D
The correct active form of the given sentence is (d) Administer the medicine every four hours.
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Active Voice- Active voice is a grammatical structure in which the subject of the sentence performs the action expressed by the verb.
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Passive Voice- Passive voice refers to a grammatical construction where the subject of a sentence undergoes an action rather than performing it. In passive voice sentences, the emphasis is on the recipient or object of the action.
The imperative sentence in active voice should command or request an action.