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Proteins are associated with a thin filament : (A) Actin (B) Myosin (C) Nebulin (D) Troponin (E) Titin Choose the correct answer from the
Question

Proteins are associated with a thin filament :
(A) Actin
(B) Myosin
(C) Nebulin
(D) Troponin
(E) Titin
Choose the correct answer from the options given below :

A.

(A), (C), (D) Only

B.

(A), (B), (E) Only

C.

(A), (C), (E) Only

D.

(A), (B), (D) Only

Correct option is A

The correct option is (a) In muscle physiology, the thin filament is a component of the sarcomere, the basic unit of muscle structure. It is primarily composed of actin, which is a globular protein that polymerizes to form filaments. Actin is essential for muscle contraction as it interacts with myosin to generate the force required for muscle movement.
myosin plays a crucial role in muscle contraction by forming cross-bridges with actin filaments and generating force. When muscles receive signals to contract, myosin heads bind to actin, causing the filaments to slide past each other. This sliding motion shortens the muscle fibers, resulting in muscle contraction. ATP provides the energy needed for myosin to repeatedly bind, pull, and release actin, allowing for continuous muscle movement.
Troponin and Tropomyosin are regulatory proteins associated with actin in the thin filament. Troponin helps regulate muscle contraction by binding to calcium ions and influencing the position of tropomyosin on actin, which in turn controls the interaction between actin and myosin during muscle contraction.
Major role in thin-filament length specification, nebulin also functions in the regulation of muscle contraction, as indicated by the findings that muscle fibers deficient in nebulin have a higher tension cost, and develop less force due to reduced myofilament calcium sensitivity and altered crossbridge cycling kinetics.

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