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    Patients on MAO inhibitors must avoid foods rich in tyramine because:
    Question

    Patients on MAO inhibitors must avoid foods rich in tyramine because:

    A.

    Tyramine causes hypoglycemia with MAOIs

    B.

    Tyramine increases serotonin, leading to serotonin syndrome

    C.

    Tyramine triggers hypertensive crisis due to norepinephrine release

    D.

    Tyramine inhibits breakdown of dopamine

    Correct option is C

    Tyramine escapes breakdown when MAO is inhibited → displaces norepinephrine → hypertensive crisis (“cheese reaction”).
    Explanation of options: (a) ✘ Tyramine has no effect on blood glucose. (b) ✘ Serotonin syndrome occurs with SSRI + MAOI, not just tyramine. (c) ✔ Correct; tyramine → norepinephrine release → severe hypertension. (d) ✘ Tyramine is metabolized by MAO, not dopamine breakdown inhibitor.

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