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    Nephrons are structural and functional units of the kidneys. Certain statements are made below about structure and function of a nephron:A. P cells of
    Question

    Nephrons are structural and functional units of the kidneys. Certain statements are made below about structure and function of a nephron:

    A. P cells of the collecting duct are involved in Na⁺ reabsorption and vasopressin-stimulated water reabsorption.
    B. P cells of the collecting duct are concerned with acid secretion and HCO₃⁻ transport.
    C. I cells of the collecting duct are concerned with acid secretion and HCO₃⁻ transport.
    D. The total length of the nephrons including collecting ducts ranges from 45 to 65 mm.

    Which one of the following options has all correct statements?

    A.

    A and B only

    B.

    B and D only

    C.

    A, C and D

    D.

    B, C and D

    Correct option is C

    Explanation:

    Let's go through the options again:

    A. P cells of the collecting duct are involved in Na+ reabsorption and vasopressin-stimulated water reabsorption.

    • This statement is correct.

      • P cells in the collecting duct are primarily involved in Na+ reabsorption and water reabsorption under the influence of vasopressin (ADH), which increases the permeability of the collecting duct to water. Hence, A is correct.

    B. P cells of the collecting duct are concerned with acid secretion and HCO₃⁻ transport.

    • This statement is incorrect.

      • P cells are involved in Na+ reabsorption and water reabsorption, not in acid secretion or bicarbonate (HCO₃⁻) transport. These functions are carried out by I cells (intercalated cells) in the collecting duct. Therefore, B is false.

    C. I cells of the collecting duct are concerned with acid secretion and HCO₃⁻ transport.

    • This statement is correct.

      • I cells (intercalated cells) are responsible for acid secretion and bicarbonate transport in the collecting duct. These cells help regulate the body's acid-base balance by secreting H⁺ ions and reabsorbing HCO₃⁻. Hence, C is correct.

    D. The total length of the nephrons, including collecting ducts, ranges from 45 to 65 mm.

    • This statement is correct.

      • The total length of the nephrons, including the collecting ducts, typically ranges from 45 to 65 mm, depending on species and the size of the kidneys. Hence, D is correct.

    Conclusion:

    • A: P cells are involved in Na+ reabsorption and vasopressin-stimulated water reabsorption.

    • C: I cells are involved in acid secretion and HCO₃⁻ transport.

    • D: The total length of the nephrons, including collecting ducts, ranges from 45 to 65 mm.

    Thus, the correct answer is Option 3: A, C and D.

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