In the question below is given a statement followed by two options numbered 1 and 2. Based on this choose the correct option.
Statement: The natural history of disease signifies the way in which a disease evolves over time.
Option 1: The earliest stage is pre-pathogenesis phase which terminates as recovery, disability or death, in the absence of treatment or prevention. Option 2: Each disease has its own unique natural history, which is not necessarily the same in all individuals.

Correct option is C

The natural history of disease describes the progression of a disease process in an individual over time, without intervention.
The earliest stage is the pre-pathogenesis phase, where the individual is exposed to risk factors but the disease has not yet developed. If prevention or treatment is absent, the disease may progress through the pathogenesis phase, ultimately ending in recovery, disability, or death. Hence, Option 1 is correct.
Each disease has a unique course of development, but its progression may vary depending on age, immunity, genetics, nutrition, and environmental conditions. Therefore, not all individuals will experience the same disease outcome in the same way. Hence, Option 2 is also correct.
Thus, both Option 1 and Option 2 are correct, making the answer Option (c).