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In eukaryotes, microtubules and actin-binding proteins influence the dynamics and organization of the cytoskeleton. Match the cytoskeleton-binding pro
Question

In eukaryotes, microtubules and actin-binding proteins influence the dynamics and organization of the cytoskeleton. Match the cytoskeleton-binding proteins listed in column B. to actin or microtubule mentioned in Column A, and their function from those listed in Column C.

Column A

Column B

Column C

X. microtubule

Y. actin

I. Ketenin

II. tropomodulin

III. tau

IV. gelsolin

A. filament cross-linking

B. severs filaments and binds to plus end

C. prevents assembly and disassembly at minus end

D. only severs filament

​Which one of the following options represents all the correct matches between column A, B and C?​

A.

X-IV-C, X-III-B, Y-I-A, Y-II-D

B.

X-II-A, X-I-C, Y-IV-C, Y-III-B

C.

 X-III-A, X-I-D, Y-II-C, Y-IV-B

D.

X-I-D, X-IV-A, Y-III-D, Y-II-C

Correct option is C

In eukaryotic cells, the cytoskeleton consists of microtubules and actin filaments that provide structural support, intracellular transport, and cell movement. These filaments interact with specialized cytoskeleton-binding proteins, which regulate their dynamics.

  • Microtubules: Composed of tubulin dimers, these are responsible for cell shape, intracellular transport, and chromosome segregation.
  • Actin Filaments: Composed of actin monomers, these contribute to cell motility, shape, and intracellular transport.
  1. Tau (iii) - Microtubules (X) - (a) Filament Cross-Linking (Correct)

    • Tau is a microtubule-associated protein (MAP) that cross-links and stabilizes microtubules, preventing depolymerization.
    • Correct match: X-(iii)-(a).
  2. Ketenin (i) - Microtubules (X) - (d) Only Severs Filament  (Correct)

    • Ketenin is known to sever microtubules but does not significantly affect their regrowth.
    • It severs microtubules into smaller fragments, disrupting the filament network.​
    • Correct match: X-(i)-(d).
  3. Tropomodulin (ii) - Actin (Y) - (c) Prevents Assembly and Disassembly at Minus End  (Correct)

    • Tropomodulin is an actin-binding protein that caps the minus end of actin filaments.
    • By capping the minus end, it prevents both polymerization and depolymerization at that site, regulating filament length.​
    • Correct match: Y-(ii)-(c).
  4. Gelsolin (iv) - Actin (Y) - (b) Severs Filaments and Binds to Plus End  (Correct)

    • Gelsolin is an actin-severing protein that plays a role in actin filament turnover.​
    • It cuts actin filaments into shorter fragments and binds to the plus end, preventing further elongation.​
    • Correct match: Y-(iv)-(b).

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