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    In eukaryotes, microtubules and actin-binding proteins influence the dynamics and organization of the cytoskeleton. Match the cytoskeleton-binding pro
    Question

    In eukaryotes, microtubules and actin-binding proteins influence the dynamics and organization of the cytoskeleton. Match the cytoskeleton-binding proteins listed in column B. to actin or microtubule mentioned in Column A, and their function from those listed in Column C.

    Column A

    Column B

    Column C

    X. microtubule

    Y. actin

    I. Ketenin

    II. tropomodulin

    III. tau

    IV. gelsolin

    A. filament cross-linking

    B. severs filaments and binds to plus end

    C. prevents assembly and disassembly at minus end

    D. only severs filament

    ​Which one of the following options represents all the correct matches between column A, B and C?​

    A.

    X-IV-C, X-III-B, Y-I-A, Y-II-D

    B.

    X-II-A, X-I-C, Y-IV-C, Y-III-B

    C.

     X-III-A, X-I-D, Y-II-C, Y-IV-B

    D.

    X-I-D, X-IV-A, Y-III-D, Y-II-C

    Correct option is C

    In eukaryotic cells, the cytoskeleton consists of microtubules and actin filaments that provide structural support, intracellular transport, and cell movement. These filaments interact with specialized cytoskeleton-binding proteins, which regulate their dynamics.

    • Microtubules: Composed of tubulin dimers, these are responsible for cell shape, intracellular transport, and chromosome segregation.
    • Actin Filaments: Composed of actin monomers, these contribute to cell motility, shape, and intracellular transport.
    1. Tau (iii) - Microtubules (X) - (a) Filament Cross-Linking (Correct)

      • Tau is a microtubule-associated protein (MAP) that cross-links and stabilizes microtubules, preventing depolymerization.
      • Correct match: X-(iii)-(a).
    2. Ketenin (i) - Microtubules (X) - (d) Only Severs Filament  (Correct)

      • Ketenin is known to sever microtubules but does not significantly affect their regrowth.
      • It severs microtubules into smaller fragments, disrupting the filament network.​
      • Correct match: X-(i)-(d).
    3. Tropomodulin (ii) - Actin (Y) - (c) Prevents Assembly and Disassembly at Minus End  (Correct)

      • Tropomodulin is an actin-binding protein that caps the minus end of actin filaments.
      • By capping the minus end, it prevents both polymerization and depolymerization at that site, regulating filament length.​
      • Correct match: Y-(ii)-(c).
    4. Gelsolin (iv) - Actin (Y) - (b) Severs Filaments and Binds to Plus End  (Correct)

      • Gelsolin is an actin-severing protein that plays a role in actin filament turnover.​
      • It cuts actin filaments into shorter fragments and binds to the plus end, preventing further elongation.​
      • Correct match: Y-(iv)-(b).

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