Given below are a few statements about vesicular transport.

A. Clathrin-mediated endocytosis requires the recruitment of adaptors to the cytosolic face of the plasma membrane.
B. The low-pH environment of early endosomes leads to the dissociation of cargo from its receptor, allowing for the recycling of receptors to the plasma membrane.
C. The late endosomes, which mature into the lysosomes, are directly involved in the recycling of synaptic vesicle proteins in neurons.
D. The multivesicular body pathway involves the formation of intraluminal vesicles, which sort cargo for degradation in the lysosomes.

Which one of the following options has all correct statements about endocytosis?

Correct option is D

EXPLANATION-

Statement A:
Clathrin-mediated endocytosis is a well-studied cellular process by which cells internalize molecules. Adaptors like AP2 proteins are recruited to the cytosolic side of the plasma membrane to help form clathrin-coated pits. These adaptors select cargo and help clathrin assemble into a coated vesicle. This statement is correct.

Statement B:
Early endosomes maintain an acidic environment (low pH), which causes ligands or cargo to dissociate from their receptors. This dissociation is crucial because it allows receptors to be recycled back to the plasma membrane while the cargo is routed for further processing.
This statement is correct.​

Statement C:
Late endosomes mature into lysosomes, which are primarily responsible for degradation of cargo. Recycling of synaptic vesicle proteins in neurons typically involves other pathways such as recycling endosomes, not directly late endosomes or lysosomes. Thus, late endosomes are not directly involved in this recycling process.
This statement is incorrect.

Statement D:
The multivesicular body (MVB) pathway involves the formation of intraluminal vesicles inside late endosomes. These vesicles contain cargo destined for degradation. This process is a key sorting step for cargo targeted to lysosomes for breakdown.
This statement is correct.

So, the correct option is (d) - A, B and D