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    Following statements were made about imprinting in the human genome. A. Imprinting control centre (IC) harbors part of the SNRPN gene. B. Imprinting o
    Question

    Following statements were made about imprinting in the human genome.
    A. Imprinting control centre (IC) harbors part of the SNRPN gene.
    B. Imprinting of genes in an individual cannot be tissue specific.
    C. Sperms and eggs exhibit identical pattern of genome methylation, except in the sex chromosomes.
    D. At imprinted loci, expression depends on the parental origin.

    Select the option with all the correct statements.

    A.

    A and D only

    B.

    B and D only

    C.

    A and C only

    D.

    B and C only

    Correct option is A

    Explanation-

    Statement A - Imprinting control centre (IC) harbors part of the SNRPN gene  - CORRECT
    The Imprinting Control Region (ICR) on chromosome 15q11-q13 includes part of the SNRPN gene, which is involved in imprinting control for the Prader-Willi and Angelman syndromes. It plays a key role in regulating parent-of-origin specific gene expression via DNA methylation.
    Statement B- Imprinting of genes in an individual cannot be tissue specific - INCORRECT
    Imprinting can be tissue-specific. Some imprinted genes are expressed in a parent-of-origin manner only in specific tissues, especially in the brain and placenta. Thus, this statement is false.
    Statement C -  Sperms and eggs exhibit identical pattern of genome methylation, except in the sex chromosomes  - INCORRECT
    Sperms and eggs have very different methylation patterns, not just on sex chromosomes but genome-wide. Genomic imprinting is established differentially in male and female germlines (sperm vs egg), and this differential methylation is critical to imprinting. Hence, this statement is false.
    Statement  D -  At imprinted loci, expression depends on the parental origin  - CORRECT
    This is the very definition of genomic imprinting. Only one allele (either maternal or paternal) is expressed, while the other is silenced, depending on its parental origin.

    Correct Option: a -  A and D only 

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