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    Chromosomal aberration in which two breaks occur in a chromosome and the intercalary segment reunites in a reverse order is categorized as:
    Question

    Chromosomal aberration in which two breaks occur in a chromosome and the intercalary segment reunites in a reverse order is categorized as:

    A.

    Duplication

    B.

    Translocation

    C.

    Inversion

    D.

    Segmental duplication

    Correct option is C

    The correct answer is: (C) Inversion
    Inversion is a type of chromosomal aberration in which a segment of a chromosome breaks at two points, reverses its orientation, and reattaches to the same chromosome.
    This leads to an altered gene sequence but does not result in loss or gain of genetic material.
    Types of Inversions:
    Paracentric Inversion → Occurs outside the centromere.
    Pericentric Inversion → Includes the centromere.
    Information Booster:

    Causes of Inversion:

      • Radiation exposure

      • Chemical mutagens

      • Errors during DNA replication

    Knowledge Booster :
    • Duplication : Extra copies of a chromosome segment appear due to replication errors. Example: Bar eye mutation in Drosophila.

    • Translocation : Exchange of genetic material between non-homologous chromosomes. Example: Philadelphia chromosome in leukemia (Chromosome 9 and 22).

    • Segmental Duplication : A segment of the chromosome is duplicated, usually larger than normal gene duplication. Example: Involved in genomic evolution and genetic disorders.

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