Administration of which contaminated vaccine may produce toxic shock syndrome?

Correct option is D

Toxic shock syndrome (TSS) is a rare but life-threatening condition that can occur following administration of a contaminated measles vaccine. Contamination may lead to the proliferation of Staphylococcus aureus or Streptococcus pyogenes, releasing toxins that trigger a systemic inflammatory response. Symptoms include high fever, rash, hypotension, and multi-organ dysfunction. This is why strict aseptic technique and proper cold chain maintenance are critical during vaccine handling.
Explanation of options: (a) DPT – Though local reactions and mild systemic effects are possible, TSS is not typically associated with DPT vaccination, even if contaminated. (b) Rabies – Adverse effects from rabies vaccines are usually neurological or allergic in nature, not toxic shock syndrome. (c) BCG – This vaccine may cause local ulceration or lymphadenitis, but it is not known to cause TSS even if compromised. (d) Measles – This is the correct answer. If the measles vaccine is contaminated, it has a known association with TSS due to bacterial endotoxin exposure.