Correct option is B
Given:
A, B, C, D, E and F are six members of a family.
There are parents, their children and grandchildren in the family.
A is the son of C and E is the daughter of A.
D is the daughter of F who is the mother of E

From the given information Family tree will be:

So, E and D are grandchildren of C.
Thus, the correct option is: (b)