When the sheet of paper given in the following figure is folded to form a cube, how many dots will be there on the side opposite to the face bearing five dots?

The logic followed here is:
From the given open Dice:

Now,

The structure is:

Top: 1 dot

Left: 4 dots

Center 1: 2 dots

Center 2: 6 dots

Bottom Left: 5 dots

So, Vertical Pair 1: The face with 1 dot is separated from the face with 6 dots by the face with 2 dots.

Hence, the correct answer is "Option C".