What is the common pathophysiological mechanism of acute pancreatitis?

Correct option is C

Ans. (c) Auto digestion of pancreas
Sol. Acute pancreatitis occurs due to the premature activation of digestive enzymes (particularly trypsin) within the pancreas, leading to self-digestion, inflammation, and tissue damage. This process triggers local and systemic inflammatory responses, resulting in pain, edema, and potential complications such as necrosis or hemorrhage.
Explanation of each option:
· (a) Overproduction of enzymes – Incorrect. The issue is not excess enzyme production, but premature activation within the pancreas.
· (b) Malabsorption of enzymes – Incorrect. Malabsorption occurs in chronic pancreatic disorders, not acute pancreatitis.
· (c) Auto digestion of pancreas – Correct answer. Pancreatic enzymes (trypsin, lipase) digest pancreatic tissue, causing inflammation and necrosis.
· (d) Formation of Neo β-Pancreatic cells – Incorrect. This is not related to pancreatitis; β-cells are responsible for insulin secretion in the pancreas.