​To ensure proper segregation of chromosomes during mitosis, the sister chromatid pairs must be stably bi-oriented on the mitotic spindle. In animal cells, after nuclear envelope breakdown (NEBD), chromosomes glide along the microtubules' length with the help of motor proteins. When the chromosomes reach the plus-end of microtubules, the kinetochores attach to the microtubules.
Which one of the following is the correct option for the kinetochore-microtubules attachment configuration that ensures proper chromosome segregation?​

Correct option is C

Explanation-

During mitosis, especially metaphase, each sister chromatid must attach to microtubules from opposite poles of the mitotic spindle to ensure they are pulled to opposite ends during anaphase. This correct attachment ensures equal segregation of chromosomes into daughter cells.

Option C -Amphitelic - Each sister kinetochore is attached to microtubules from opposite poles. This ensures bipolar orientation, proper tension, and equal segregation.

Incorrect options-

Option A - Monotelic
Only one kinetochore of the sister chromatid pair is attached to microtubules from one spindle pole.
Incorrect, as the other sister is unconnected and won’t segregate properly.
Option B - Merotelic
One kinetochore is attached to microtubules from both poles.
Leads to tug-of-war, possible chromosome lagging, and missegregation.
Option D - Syntelic
Both sister kinetochores are attached to microtubules from the same pole.
No separation occurs; both chromatids go to one daughter cell → aneuploidy.

So, the correct answer is option C - Amphitelic
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