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    ​The following table summarizes the key signaling pathways that orchestrate development, their receptors, transcription effectors, and outputs:​​Which
    Question

    The following table summarizes the key signaling pathways that orchestrate development, their receptors, transcription effectors, and outputs:

    ​​Which of the above pathways are correctly matched?

    A.

    A, C and D

    B.

    Only B and E

    C.

    Only A and D

    D.

    Only C and E

    Correct option is D

    Explanation-

    A. Wnt Pathway
    Receptor listed as Thick veins — this is incorrect.
    Correct receptor for Wnt: Frizzled
    Transcriptional effector β-catenin is correct.
    Output “Patterning” is also correct.
    Result:Incorrect (because of wrong receptor)

    B. Hedgehog Pathway
    Receptor listed as Frizzled — Incorrect.
    Correct receptor: Patched
    Ci/Gli is correct effector.
    Output “Growth” is reasonable.
    Result:Incorrect (wrong receptor)

    C. RTK Pathway
    EGFR receptor 
    Pointed/Yan effectors 
    Output “Morphogenesis” 
    Result: Correct

    D. TGFβ Pathway
    Receptor listed as Patched —  Incorrect.
    Correct receptor: TGFβR (type I and II receptors)
    Effector NICD —  actually belongs to Notch pathway
    Result: Incorrect

    E. JNK Pathway
    Receptor: TNF 
    Effector: Jun/Fos 
    Output: Migration 
    Result:Correct

    Final Answer - Only C and E are correctly depicted.
    Option d (Only C and E) is correct.









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