Correct option is A
In this question following logic is followed-
(1st + 3rd )2 = 2nd Number
4, 81, 5 → (4 + 5)2 = 92 = 81
3, 144, 9 → (3 +9)2 = 122 = 144
Similarly,
2, 100, 8 → (2 + 8)2 = 102 = 100
Therefore, the correct answer is (a).