Correct option is C
The option that can be used as a one-word substitute for the given group of words "A place to play games and bet on them" is (c) "Casino."
A casino is a facility where people can play various games of chance and often place bets on them.
Meanings of the other options:
Motel: A roadside hotel typically designed for travelers, providing parking facilities.
Hotel: An establishment that provides lodging accommodations and often other services to travelers.
Pub: A public house where alcoholic beverages are served, often a place for socializing but not primarily for gambling.