Correct option is C
The most appropriate synonym of the bracketed word "mutate" to fill in the blank in the sentence is option (c) “change”.
Mutate means to undergo a change or genetic alteration.
Replicate means to copy or reproduce something. It does not necessarily imply a change.
Imitate means to mimic or copy someone or something. Again, it does not imply a change.
Incise means to cut or carve into something. It does not fit in the context of the sentence.