Select the most appropriate option that can substitute the highlighted segment in the given sentence.
I still enjoyed the week despite of the weather.

Correct option is D

The most appropriate option to substitute the highlighted segment "despite of the weather" is (d) despite the weather.
 The correct usage of "despite" is to simply follow it with a noun or a noun phrase, without the use of any prepositions such as "of," "with," or "for."
 Therefore, "despite the weather" is the correct way to phrase it.