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    Segregation of alleles can occur either at anaphase I or anaphase II of meiosis. Which one of the following is an ideal model system for identifying t
    Question

    Segregation of alleles can occur either at anaphase I or anaphase II of meiosis. Which one of the following is an ideal model system for identifying the stage at which allelic segregation occurred?

    A.

    ​Arabidopsis thaliana

    B.

    Drosophila melanogaster

    C.

    ​Neurospora crassa

    D.

    Saccharomyces cerevisiae

    Correct option is C

    Neurospora crassa (Fungi) is an ideal model system for studying the segregation of alleles during meiosis because it exhibits a linear arrangement of ascospores within the ascus. This allows direct observation of the products of meiosis and mitosis in a sequential order, making it possible to determine at which stage (Anaphase I or Anaphase II) allelic segregation has occurred.

    •  Neurospora crassa: 
      • It undergoes ordered tetrad analysis, which allows researchers to track the segregation of alleles.
      • The arrangement of meiotic products (ascospores) in a linear order reflects the order of chromosome segregation.
      • This model system provides insights into crossing-over and chromosomal behavior during meiosis.

    Thus, Neurospora crassa is widely used to determine whether allele segregation occurs at Anaphase I (homologous chromosome separation) or Anaphase II (sister chromatid separation).

    Information Booster

    1. Meiosis Overview: Meiosis consists of two divisions—Meiosis I (reductional division) and Meiosis II (equational division).
    2. Anaphase I vs. Anaphase II:
      • Anaphase I: Homologous chromosomes segregate.
      • Anaphase II: Sister chromatids segregate.
    3. Tetrad Analysis in Neurospora:
      • The ordered tetrads of Neurospora crassa allow precise tracking of allele segregation.
    4. First-Division Segregation (FDS): If alleles separate at Anaphase I, all spores of the same type are grouped together.
    5. Second-Division Segregation (SDS): If alleles separate at Anaphase II, crossover events can be detected by mixed spore arrangements.

    Additional Information

    • Option (1) Arabidopsis thaliana (Incorrect)

      • A model plant used in genetics, but not ideal for directly observing meiotic segregation due to its random spore arrangement.
    • Option (2) Drosophila melanogaster (Incorrect)

      • A widely used genetic model, but meiosis occurs in specialized germ cells, making direct observation of allelic segregation difficult.
    • Option (4) Saccharomyces cerevisiae (Incorrect)

      • A model yeast used in genetics and meiosis studies, but it undergoes unordered tetrad formation, making it less suitable for tracking specific segregation events.

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