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Read the following Assertion (A) and Reason (R) carefully and choose the correct option: Assertion (A): In eukaryotic cells, the majority of ATP pr
Question

Read the following Assertion (A) and Reason (R) carefully and choose the correct option:
Assertion (A): In eukaryotic cells, the majority of ATP produced during aerobic respiration is generated through oxidative phosphorylation in the mitochondria.
Reason (R): Oxidative phosphorylation relies on a proton gradient across the inner mitochondrial membrane, established by the electron transport chain, which drives ATP synthesis via chemiosmosis.

A.

(A) is false, but (R) is true

B.

Both (A) and (R) are true, but (R) is not the correct explanation of (A)

C.

(A) is true, but (R) is false

D.

Both (A) and (R) are true, and (R) is the correct explanation of (A)

Correct option is D

The correct answer is (d) Both (A) and (R) are true, and (R) is the correct explanation of (A)

Explanation:

  • Assertion (A) is true: While glycolysis and the TCA cycle produce some ATP directly, about 90% of the ATP in aerobic respiration is generated in the final stage.
  • Reason (R) is true: The Electron Transport Chain (ETC) pumps protons into the intermembrane space.
  • The resulting proton motive force drives protons back through ATP synthase.
  • This process of using a proton gradient to synthesize ATP is known as chemiosmosis, proposed by Peter Mitchell.
  • Since R describes exactly how the ATP mentioned in A is produced, it is the correct explanation.

Information Booster:
  • The inner mitochondrial membrane is folded into cristae to increase surface area for these reactions.
  • One molecule of NADH produces approximately 2.5 ATP, and one FADH2 produces 1.5 ATP.

Additional Knowledge:
A is false, R is true (Option a)
  • Incorrect; A is a fundamental concept of cellular biology.

Both true, R not explanation (Option b)
  • Incorrect; the mechanism in R is the direct cause of the efficiency noted in A.

A is true, R is false (Option c)
  • Incorrect; R accurately describes the Chemiosmotic Hypothesis.

So the correct answer is (d)

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