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Negri bodies in the brain commonly occur in:
Question

Negri bodies in the brain commonly occur in:

A.

Measles

B.

Polio

C.

Rabies

D.

Tetanus

Correct option is C

Negri bodies are eosinophilic, intracytoplasmic inclusion bodies found in the neurons of the hippocampus and cerebellum of rabies-infected individuals. They are a hallmark microscopic finding in postmortem diagnosis of rabies. The rabies virus travels retrogradely along peripheral nerves to the CNS where it causes encephalitis.
Explanation of options: (a) ✘ Measles – Causes subacute sclerosing panencephalitis (SSPE), not Negri bodies. (b) ✘ Polio – Affects motor neurons leading to paralysis but doesn’t produce Negri bodies. (c) ✔ Rabies – Characterized by the presence of Negri bodies in neurons. (d) ✘ Tetanus – Caused by a bacterial toxin affecting neuromuscular function, not involving Negri bodies.

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