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Mutants and transgenic models have played a pivotal role in understanding development. Which one of the following statements is true?
Question

Mutants and transgenic models have played a pivotal role in understanding development. Which one of the following statements is true?

A.

A transgenic DNA chimaera experiment involves the transplantation of cells from a genetically modified organism to another embryo.

B.

Interspecies chimaera are the easiest and most common model systems to study developmental processes.

C.

A transgenic female mouse (XX) expressing Sry (sex-determining region of the Y-chromosome) induces the production of Y-chromosome-carrying ovum in the mouse.

D.

A transgenic animal model is exclusively utilized to study gene function by deletion of a gene.

Correct option is A

The correct answer is: (1) A transgenic DNA chimaera experiment involves the transplantation of cells from a genetically modified organism to another embryo.

Explanation:
In a transgenic DNA chimaera experiment, genetically modified cells (from a transgenic organism) are transplanted into a developing embryo, where they integrate and contribute to the development of the organism. This process helps in studying the roles of specific genes by observing the development of the modified cells within a whole organism. This experiment is crucial in understanding how genes affect development at the organismal level. The other options contain inaccuracies regarding the usage of transgenic models.

Information Booster:

  1. A chimaera involves combining two or more embryos (or cells from different embryos) into one organism, resulting in an organism with tissues from both sources.

  2. Transgenic DNA chimaera experiments allow researchers to study the function of specific genes by analyzing how cells carrying the genetic modification behave within a whole, living organism.

  3. This approach is particularly useful for investigating developmental processes and understanding how specific genes contribute to growth and differentiation.

Additional Knowledge:

  • Interspecies chimaera (option 2) are not the most common model system for studying development, and creating interspecies chimaeras is often challenging and not typically used for developmental processes. Most chimaeras are created within a single species.

  • The statement about the transgenic mouse expressing Sry (option 3) is incorrect because the Sry gene in a female mouse would not lead to the production of Y-chromosome-carrying ovum. The Sry gene is crucial for male development and is typically active in male (XY) mice.

  • Transgenic animal models (option 4) can be used in a variety of ways, including overexpression, knockdown, or knock-out of genes, and are not exclusively for studying gene function by gene deletion.

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