Correct option is D
A. Vitamin A deficiency can be defined clinically or sub-clinically. Xerophthalmia is the clinical spectrum of ocular manifestations of vitamin A deficiency; these range from the milder stages of night blindness and Bitot spots to the potentially blinding stages of corneal xerosis, ulceration and necrosis (keratomalacia).
B. Thiamine deficiency (causing beriberi and other problems) is most common among people whose diet mainly consists of white rice or highly processed carbohydrates in countries with high rates of food insecurity and among people with alcohol use disorder.
C. Addison's disease is caused by damage to the adrenal glands. The adrenal glands sit just above the kidneys. As part of the endocrine system, they make hormones that affect almost every organ and tissue in the body. Damage to these glands results in too little of the hormone cortisol and, often, the hormone aldosterone.
D. Estradiol is needed to maintain the eggs inside a female's ovaries. During the menstrual cycle, follicles on the ovaries secrete estradiol, which triggers a series of events that lead to a surge in luteinizing hormone and, in turn, induces ovulation.
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