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In the lac operon model, what is the primary role of the allolactose molecule?
Question

In the lac operon model, what is the primary role of the allolactose molecule?

A.

It functions as an inducer, binding to the repressor protein and inactivating it.

B.

It acts as a corepressor, binding with the repressor protein.

C.

It binds to the promoter to initiate transcription.

D.

It directly codes for the enzymes involved in lactose metabolism.

Correct option is A

The correct answer is: (a) It functions as an inducer, binding to the repressor protein and inactivating it.
Explanation:
· In the lac operon model of E. coli, allolactose (an isomer of lactose) acts as an inducer.
· It binds to the repressor protein (LacI), causing a conformational change that prevents the repressor from binding to the operator.
· This allows RNA polymerase to transcribe the structural genes (lacZ, lacY, lacA) for lactose metabolism.
Information Booster:
· The lac operon is a classic example of inducible operon.
· Discovered by François Jacob and Jacques Monod (1961).
· lacZ → β-galactosidase (breaks lactose → glucose + galactose).
· lacY → Permease (helps lactose enter the cell).
· lacA → Transacetylase (detoxifies by-products).
Additional Knowledge:
· (b) Incorrect → Corepressors usually enhance repression (e.g., tryptophan in trp operon).
· (c) Incorrect → Promoter binding is by RNA polymerase, not allolactose.
· (d) Incorrect → Allolactose is not a gene; it doesn’t code for enzymes.

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