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In a randomized controlled trial (RCT) testing a new antihypertensive drug, both patients and treating physicians are kept blinded to group allocation
Question

In a randomized controlled trial (RCT) testing a new antihypertensive drug, both patients and treating physicians are kept blinded to group allocation. Which bias is most directly minimized by this approach?

A.

Selection bias

B.

Detection bias

C.

Performance bias

D.

Recall bias

Correct option is C

Blinding prevents differences in care, attention, or co-interventions between groups. This minimizes performance bias, which arises if providers or participants alter behavior because they know allocation.
Explanation of options: (a) ✘ Selection bias is reduced by randomization, not blinding. (b) ✘ Detection bias is reduced by blinded outcome assessment, but here the focus is on treatment delivery. (c) ✔ Correct; blinding minimizes performance bias → ensures equal treatment apart from the intervention. (d) ✘ Recall bias occurs in retrospective self-reported studies, not in RCTs.

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