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In 2022, Svante Pääbo was awarded the Nobel Prize in Physiology or Medicine for his groundbreaking work in which area?
Question

In 2022, Svante Pääbo was awarded the Nobel Prize in Physiology or Medicine for his groundbreaking work in which area?

A.

Discoveries concerning the genomes of extinct hominins and human evolution

B.

Mapping the human proteome

C.

Pioneering stem cell research

D.

Developing the first synthetic genome

Correct option is A

The correct answer is (a) Discoveries concerning the genomes of extinct hominins and human evolution

Explanation:

  • Svante Pääbo achieved the seemingly impossible task of sequencing the genome of the Neanderthal, an extinct relative of present-day humans.
  • He also discovered a previously unknown hominin, Denisova.
  • His work established an entirely new scientific discipline: Paleogenomics.
  • He found that gene transfer had occurred from these extinct hominins to Homo sapiens following the migration out of Africa.
  • This ancient gene flow has physiological relevance today, such as affecting our immune system's response to infections.

Information Booster:
  • He is the director at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.
  • Pääbo's father, Sune Bergström, also won a Nobel Prize in Medicine (1982).

Additional Knowledge:
Mapping the human proteome (Option b)
  • Incorrect; while significant, this was not the basis for the 2022 Nobel Prize.

Stem cell research (Option c)
  • Incorrect; Shinya Yamanaka and John Gurdon won in 2012 for this field.

Synthetic genome (Option d)
  • Incorrect; J. Craig Venter is a key figure here, but it has not been awarded a Nobel Prize for Medicine recently.

So the correct answer is (a)

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