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    ​Given below are statements about development in different model organisms:A. Xenopus egg has yolk and hence undergoes meroblastic cleavage. B. Embryo
    Question

    Given below are statements about development in different model organisms:

    A. Xenopus egg has yolk and hence undergoes meroblastic cleavage.
    B. Embryonically transcribed β-catenin in the blastomeres of sea urchin embryos regulates the autonomous specification of micromeres.
    C. The sodium pump activity in the trophoblast helps in the formation of the blastocoel of a mammalian blastocyst.
    D. Prevention of tubal pregnancy is one of the major functions of the zona pellucida in humans.

    Which combination of the statements is true?

    A.

    ​A and B

    B.

    ​A and C

    C.

    ​B and D

    D.

    C and D

    Correct option is D

    Explanation:

    Statement A: Incorrect

    • Xenopus eggs have yolk, but they undergo holoblastic (not meroblastic) cleavage.
    • Holoblastic cleavage occurs when the entire egg divides, though unevenly due to yolk presence.
    • Meroblastic cleavage occurs when only part of the egg divides (e.g., in birds and fish).

    Statement B: Incorrect

    Embryonically transcribed β-catenin in the blastomeres of sea urchin embryos regulates the autonomous specification of micromeres.

    ·       β-catenin itself does not directly regulate autonomous specification in sea urchin micromeres. Instead, it is a key player in conditional specification and later mesodermal and endodermal lineage specification.

    Statement C: Correct

    The sodium pump activity in the trophoblast helps in the formation of the blastocoel of a mammalian blastocyst.

    ·       the formation of the blastocoel in a mammalian blastocyst is driven by sodium (Na⁺) and water transport through the trophoblast (specifically, the trophectoderm layer).

    Statement D: Correct

    • The zona pellucida (ZP) prevents polyspermy and ectopic (tubal) pregnancy.
    • The ZP hardens after fertilization to prevent further sperm entry (cortical reaction).
    • It keeps the fertilized egg from implanting too early, ensuring it reaches the uterus before attachment.

    Information Booster

    ·       Cleavage in Xenopus → Holoblastic cleavage, not meroblastic, as cleavage occurs throughout the egg despite yolk presence.

    ·       β-Catenin in Sea Urchins → Regulates mesoderm and endoderm fate, but micromere specification is controlled by maternal factors (Disheveled, Pmar1), not embryonically transcribed β-catenin.

    ·       Sodium Pump in Trophoblast → Na⁺/K⁺ ATPase in the trophectoderm creates an osmotic gradient, drawing water into the blastocoel, essential for blastocyst formation.

    ·       Zona Pellucida in Humans → Prevents polyspermy, regulates sperm binding, and prevents premature implantation (reducing risk of tubal pregnancy).

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