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Given below are inhibitors of electron transport (Column X) and their target enzymes (Column Y)Column X Inhibitors of electron transportColumn Y Respi
Question

Given below are inhibitors of electron transport (Column X) and their target enzymes (Column Y)

Column X Inhibitors of electron transport

Column Y Respiratory chain complex enzymes

A.

Dicyclohexylcarbodiimide and Oligomycin

I.

NADH coenzyme Q reductase

B.

Rotenone and Demerol

II.

ATP Synthase

C.

Thenoyltrifluroacetone and Carboxin

III.

Succinate coenzyme Q reductase

D.

Cyanide and Azide

IV.

Cytochrome c oxidase

Which one of the following options represents all correct matches between Column X and Column Y?

A.

A-III, B-IV, C-I, D-II

B.

A-II, B-I, C-III, D-IV

C.

A-IV, B-II, C-I, D-III

D.

A-I, B-III, C-IV, D-II

Correct option is B

Explanation: This question asks to match the inhibitors of the electron transport chain with their target enzymes. Here’s the breakdown:

  • A) Dicyclohexylcarbodiimide and Oligomycin inhibit ATP Synthase (complex V), which is responsible for synthesizing ATP during oxidative phosphorylation. Therefore, the correct match is (ii).

  • B) Rotenone and Demerol inhibit NADH coenzyme Q reductase (complex I), which is responsible for transferring electrons from NADH to coenzyme Q. Therefore, the correct match is (i).

  • C) Thenoyltrifluoroacetone and Carboxin inhibit Succinate coenzyme Q reductase (complex II), which is involved in transferring electrons from succinate to coenzyme Q. Therefore, the correct match is (iii).

  • D) Cyanide and Azide inhibit Cytochrome c oxidase (complex IV), which is responsible for transferring electrons to oxygen. Therefore, the correct match is (iv).

Information Booster:

  1. ATP Synthase (complex V) is essential for ATP production, and its inhibition leads to a halt in cellular energy production.

  2. NADH coenzyme Q reductase (complex I) plays a crucial role in the electron transport chain by transferring electrons from NADH to coenzyme Q.

  3. Succinate coenzyme Q reductase (complex II) is involved in the transfer of electrons from succinate to coenzyme Q and is a point of inhibition for substances like Carboxin and Thenoyltrifluoroacetone.

  4. Cytochrome c oxidase (complex IV) is the terminal enzyme complex in the electron transport chain, responsible for transferring electrons to oxygen and completing the electron transfer process.

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