Correct option is D
C is second from one extreme end, while fourth from the other extreme end.
_,C,_,_,_ or _,_,_,C,_,
B and D sit at the extreme ends of the row.
B/D,C,_,_,B/D or B/D,_,_,C,B/D
A is not at the exact centre position of the row.
B/D,C,_,A,B/D or B/D,A,_,C,B/D
Remaining E will sit in middle empty position in both cases.
answer is E