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    A pregnant woman on methyldopa for hypertension notices her urine turning dark on standing. What is the best advice to give her?
    Question

    A pregnant woman on methyldopa for hypertension notices her urine turning dark on standing. What is the best advice to give her?

    A.

    Stop the drug immediately

    B.

    This is a harmless side effect; continue therapy

    C.

    Switch to another antihypertensive

    D.

    Increase fluid intake to dilute urine

    Correct option is B

    Methyldopa can cause harmless dark coloration of urine due to oxidation of metabolites. No treatment change is required.
    Explanation of options: (a) ✘ Not necessary unless other side effects occur. (b) ✔ Correct; harmless discoloration is expected. (c) ✘ Switching is not indicated for this benign side effect. (d) ✘ Fluids won’t alter metabolite excretion.

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