A 29-year-old woman has three consecutive pregnancy losses at <10 weeks gestation. Investigations show positive lupus anticoagulant and anticardiolipin antibodies. Most likely cause is:

Correct option is B

Recurrent early pregnancy losses with positive lupus anticoagulant indicate APLA syndrome → causes hypercoagulability, placental thrombosis, and miscarriage.
Explanation of options: (a) ✘ Chromosomal translocations cause sporadic, not recurrent losses. (b) ✔ Correct; APLA is leading maternal cause of recurrent early miscarriage. (c) ✘ Cervical incompetence causes 2nd trimester loss, not early. (d) ✘ Hypothyroidism can cause miscarriage, but not typically recurrent with positive antibodies.